Humanin (HN), a mitochondrial peptide, has been proven in recent research to protect against neuronal cell death, such as that seen in Alzheimer’s. Researchers at the Experimental Biology conference in New Orleans have shown that a modest infusion of HN is the most impactful regulator of insulin metabolism that they’ve ever observed in diabetic rats. It significantly boosts overall insulin sensitivity and drastically reduces glucose levels.
For the first time, licensed professionals have discovered a function for HN in glucose metabolism, which might help explain the development of various age-related disorders, including Type 2 Diabetes Mellitus and Alzheimer’s. As a result of these findings, it is now widely accepted that the brain (in addition to the pancreas, liver, and other peripheral organs) plays a vital role in glucose metabolism.
As a result, Dr. Barzilai, who is the Ingeborg and Ira Leon Rennert Chair of Aging Research and Director of Albert Einstein College of Medicine’s Institute for Aging Research, believes that HN’s effect on insulin activity indicates a novel therapeutic approach to diabetes. There may be ways to prevent age-related illnesses such as Alzheimer’s and Parkinson’s by better understanding how HN interacts with the growth hormone/insulin-like growth factor system.
The American Society for Biochemistry and Molecular Biology’s scientific program includes Dr. Barzilai’s lecture at Experimental Biology. Barzilai is widely regarded as one of the world’s foremost researchers of longevity genes, particularly those he has uncovered in a sample of almost 500 subjects aged 95 to 112 and their relatives. Last year, some of the oldest individuals had mutations in the insulin-like growth factor 1 (IGF-1) receptor gene, which has been demonstrated to increase the life span of worms and certain animals in the laboratory. While HN production declines with age, centenarians and their progeny had the most significant levels of HN production, according to a presentation in Experimental Biology. The HN gene in the mitochondria of centenarians is now the subject of research at the Institute for Aging Research.
Is it possible to see how these genes interact? According to researchers, even though there is still more to be discovered, professional teams are getting a better grasp on how HN works in conjunction with the GH/IGF system. IGFBP-3 (insulin-like growth factor binding protein-3) binds Humanin and influences cell survival promotion, discovered in previous investigations.
HN’s effects on insulin were likewise shown to be mitigated by IGFBP-3 in this latest research. The peptide’s impact was amplified due to IGFBP-3 inhibition. As licensed professionals point out, this offers a pharmacological target.
HN’s efficacy in people cannot be predicted in the preclinical testing phase, but researchers are encouraged by the natural peptide’s capacity to protect cells. Anti-diabetic medicines may raise the risk of cardiovascular disease. Rats given Humanin before or after suffering heart attacks by Dr. Barzilai’s team saw a 50% reduction in infarct size compared to rats not given the peptide. If you are a licensed professional interested in further conducting studies on this compound, you can buy Humanin peptide online for research purposes only.
